Prescription Required.Why?
A tricyclic antidepressant (tca) medication.
An anticonvulsant and analgesic medication belonging to the gabapentinoid class.
Treatment of neuropathic pain (nerve pain)
Management of fibromyalgia
Treatment of generalized anxiety disorder (GAD) in some cases, though this is often with amitriptyline alone.
Treatment of depressive disorders (primarily with amitriptyline)
Amitriptyline works by blocking the reuptake of serotonin and norepinephrine in the brain, while pregabalin binds to voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters. This combination offers both antidepressant and analgesic effects, especially beneficial for managing neuropathic pain.
Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication according to your pharmacist's instructions.
Dosage is strictly individualized and determined by a physician based on the patient's condition, response to treatment, and overall health. It is crucial to follow prescribed dosage and frequency precisely.
Do not abruptly stop taking this medication without consulting your doctor.
The medication may be taken with or without food, as directed by your physician
Orthostatic hypotension (sudden drop in blood pressure upon standing)
Cardiac effects (rare but serious, particularly with amitriptyline)
Drowsiness
Dizziness
Dry mouth
Constipation
Weight gain
Blurred vision
Nausea
Headache
Sedation
Confusion
Alcohol should be avoided or consumed minimally as it can exacerbate drowsiness and other side effects.
Avoid driving or operating machinery until you know how this medication affects you, as it may cause drowsiness and impair your judgment and reaction time.
Consult your doctor immediately before taking this medication if you are pregnant, breastfeeding, or planning to become pregnant. Use is generally avoided during pregnancy and breastfeeding unless the potential benefits outweigh the risks. This should only be determined in consultation with your doctor.
This combination is not generally recommended for children. Treatment should be carefully weighed against the risks by a medical professional.
Dosage may need to be adjusted in patients with kidney impairment. Your physician should monitor kidney function.
Dosage may need to be adjusted in patients with liver impairment. Your physician should monitor liver function.
Consult your doctor or pharmacist for detailed information and references to specific studies.
