Is the active ingredient.
Treatment of hyponatremia (low sodium levels in the blood) in hospitalized adults with euvolemic or hypervolemic hyponatremia, particularly those with heart failure, cirrhosis, or syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Shiokem 30mg Tablet (Tolvaptan) is a selective vasopressin V2 receptor antagonist. It blocks the action of vasopressin (antidiuretic hormone) on the kidneys, reducing the reabsorption of water and increasing the excretion of free water in the urine, thereby helping to correct hyponatremia.
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Discard any unused medication after the expiration date.
Dosage should be determined by a healthcare professional and adjusted based on individual patient response and serum sodium levels.
Typically administered orally, with or without food.
Dosage may start low and be gradually increased, as per doctor's prescription.
Increased thirst
Increased urination (polyuria)
Dry mouth
Headache
Dizziness
Nausea
Muscle cramps
Hypotension (low blood pressure)
Elevated liver enzymes
Kidney problems
Severe hyponatremia (rare but potentially fatal).
Avoid alcohol consumption while taking tolvaptan, as it can exacerbate dehydration and side effects.
Tolvaptan may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how it affects you.
Tolvaptan should only be used during pregnancy or breastfeeding if the potential benefits outweigh the potential risks. Consult your doctor.
The safety and effectiveness of tolvaptan in children have not been established.
Use with caution in patients with impaired kidney function. Dosage adjustment may be necessary.
Use with caution in patients with impaired liver function. Monitor liver enzymes regularly.
Your prescribing physician
The package insert accompanying the medication
Reputable medical websites and journals (e.g., FDA website, PubMed)
