Is the active pharmaceutical ingredient.
Treatment of ovarian cancer (relapsed or refractory)
Treatment of small cell lung cancer (relapsed or refractory)
Hycamtin 1mg Tab (Topotecan) is a topoisomerase I inhibitor. It works by preventing the enzyme topoisomerase I from resealing DNA breaks, leading to DNA damage and ultimately cell death in rapidly dividing cancer cells.
Store Topotecan at room temperature (20-25°C), away from light and moisture. Keep out of reach of children. Discard any unused medication after its expiration date.
Dosage and administration of topotecan vary widely depending on the specific cancer type, the patient's overall health, and other factors. Always follow the instructions provided by your doctor or pharmacist.
It's typically administered intravenously (IV) over a specific period of time.
Neutropenia (low white blood cell count)
Thrombocytopenia (low platelet count)
Anemia (low red blood cell count)
Nausea and vomiting
Diarrhea
Alopecia (hair loss)
Mucositis (inflammation of the mucous membranes)
Fatigue
Elevated liver enzymes
Alcohol consumption may increase the risk of side effects, especially gastrointestinal issues. Discuss alcohol consumption with your healthcare provider.
Topotecan may cause fatigue, dizziness, or other side effects that could impair your ability to drive or operate machinery. Avoid driving or operating machinery if affected.
Topotecan is known to be harmful to a developing fetus. Pregnant and breastfeeding women should not use this medication. Effective contraception should be used.
Topotecan is not typically used in children. The use of Topotecan in this population has not been fully established.
Kidney impairment may affect the elimination of topotecan. Your dose may need to be adjusted if you have kidney problems.
Liver impairment may affect the metabolism of topotecan. Your dose may need to be adjusted if you have liver problems.
Package insert of the specific Topotecan formulation
National Cancer Institute (NCI) website
Relevant medical journals and databases (e.g., PubMed)
